F. H. George is Professor of Cybernetics at Brunel University in England. His book comprises eight chapters originally developed as lectures for a non-specialist audience. He points out the position of computer science among the sciences, explains its aims, procedures, and achievements to date, and speculates on its long-term implications for science in particular and society in general. Among the topics discussed are biological simulation and organ replacement, automated education, and the new philosophy of science. Each chapter concludes with a (...) brief summary. George's treatment of the technical details of his speciality is both illuminating and readable, thus serving as an excellent primer on one of the new technology's most important components. His wider forays into philosophy, economics, sociology, and religion are less happy, however; and unfortunately they take up a large part of the text. In general, they reveal that George identifies the methods of human advancement with the methods of the natural sciences in an equation whose rigidity would make even B. F. Skinner blush. Yet, the reader cannot claim that he was not forewarned; for in the introduction, D. J. Stewart, Chairman of the Rationalist Press Association, suggests that the current "swing of interest among young people away from the physical and biological sciences and towards the behavioural and social sciences... represents a symptom of disillusionment with science and technology and an attempted escape into irrationality."--J. M. V. (shrink)

This volume consists of seven contributions to a symposium held in 1970 to commemorate the centennial of Saint John's University. Carlo Giacon and Bernard Cohen explicate the relationship of philosophy and modern science. Joseph Owens and John E. Smith treat the question of God as it is posed in philosophy today. Richard McKeon interrelates humanism, civility, and culture; while Vernon Bourke evaluates humanism as a possible basis for moral philosophy. Finally, Paul Ramsey offers some pithy comments on the present trend (...) which abhors man's irreverence for the non-human environment but waxes enthusiastic over the prospect of man's limitless self-modification. Though these papers are brief, for the most part they are extensively footnoted; and thus they provide a handy survey of current thinking on the indicated issues.--J. M. V. (shrink)

In this, his first book, originally published in 1926, Henry Nelson Wieman sets forth a view on the relationship of religious experience and scientific method which in substance he has maintained ever since. According to Wieman, our knowledge of the concrete world consists of immediate sensuous experience as interpreted through some set of concepts. Religious experience is the richest form of immediate sensuous experience. It is our awareness of God, who is as much an object of experience as are tree (...) and hill and stone. And scientific method is the systematic procedure by which the conceptual network for interpreting immediate sensuous experience is clarified and corrected, with the experience-concept compound thus becoming "science." Religious experience, therefore, receives its most adequate interpretation in science; while science, in turn, receives its most stimulating input from religious experience. In principle, the highest of the individual sciences is theology; in fact, however, the very complexity of religious experience and the difficulty of distinguishing it clearly from other types of immediate sensuous experience have prevented more than merely minimal progress in achieving a truly scientific theology. On the whole our ideas about God are marked by confusion and controversy, therefore, despite the fact that some of these notions probably are true. Wieman’s book serves as an excellent example of the liberal thought which dominated much of theology and philosophy-of-religion during the last part of the nineteenth century and the first part of the twentieth. The religious thinker with a liberal perspective conceives his primary challenge as developing a scientifically acceptable interpretation of religious experience, taking that experience itself as being obvious and almost universally recognized. One need not be particularly well read to know that current judgments regarding the obviousness of religious experience are hardly so sanguine, however, and that the religious thinker typical of our own age therefore conceives his primary challenge quite differently.—J. M. V. (shrink)

Butchvarov is chairman of the department of philosophy at the University of Iowa. His book, a contribution to a new series, the Northwestern University Publications in Analytical Philosophy, deals with "the conceptual foundations of epistemology." It is divided into four main parts. The first undertakes an account of the general concept of knowledge. The second treats the objects of a priori knowledge; the third, the nature of primary a posteriori knowledge. The fourth part regards nondemonstrative inference and the nature of (...) derivative knowledge in general. The focus of the book is upon fundamental epistemic concepts rather than such particular issues as knowledge of the future, of bodies, of other minds, etc. Butchvarov urges that such specialized problems be treated only after the general conceptual framework has been investigated, lest one's common-sense opinions on the former unduly influence his philosophical conclusions as to the latter. For the inherent demands of the discipline itself must be respected: "In philosophy, as in any other purely theoretical discipline, it is better to be wrong as the result of inquiry and argument than to be right as the result of mere conviction." One of the author's central conclusions concerns evidential criteria. One unquestionable criterion of evidence is the impossibility of mistake, the "demonstrative" criterion. Is there, in addition, any "nondemonstrative" criterion of evidence, with the consequent possibility of nondemonstrative derivative knowledge or at least nondemonstrative rational belief? While not ruling out the possibility of such a criterion, Butchvarov judges that at least one has not yet been brought forth. Particular criteria proposed as nondemonstrative, such as inductive and behavioral, either presuppose the demonstrative criterion or else lack intelligible content. More generally, the nondemonstrative criterion either would or would not possess something in common with the demonstrative criterion, such that both could be understood as species of the same genus, "criterion of evidence." But no successful attempt has thus far been made in showing just what this shared trait might be; and the thesis that there can be multiple criteria of evidence without any generic commonality equivocates on the very notion of evidence. It follows, therefore, that knowledge and rational belief are much more restricted than one would ordinarily surmise. This book manifests both the scholar's mastery of his field and the teacher's concern for clear, well-structured presentation. It reads well, employs good examples, and includes the all-important index.--J. M. V. (shrink)

Anders Nygren is widely known among English-speaking readers for his subtle and scholarly analysis of the forms of love, Agape and Eros, first published in 1930. Important facets of his far-ranging thought, however, have remained largely inaccessible to those who do not read Swedish. The present volume is a significant step in reducing that inaccessibility. Nygren's work is treated by seventeen different contributors in essays grouped under the following headings: Philosophy of Religion, Motif Research, The Meanings of Love, Systematic Theology, (...) Ethics, and Cultural and Ecumenical Concerns. Yet the book is more than merely a Festschrift. Over ten years in preparation, it aims at criticism as well as interpretation; and it includes an introductory "intellectual autobiography" by Nygren himself, a concluding response by Nygren to each of his critics, and a complete bibliography chronicling the 372 items published by Nygren from 1918 through 1970. Nygren's investigations fall on both sides of the line between philosophy and theology. The interest which unifies these inquiries is the philosophy of religion. "It is above all in the philosophy of religion that the great decisions are finally made." Nygren's earliest work was an attempt to establish the philosophy of religion on a purely scientific basis. It was in this regard that he developed his characteristic method of "motif research." Just as the supreme theoretical, aesthetic, and ethical categories are the true, the beautiful, and the good, respectively, so the supreme religious category is the eternal. All these categories are merely formal, however, and one must turn to the particular for content. Now, content in the theoretical domain consists of factual relationships; but content in the remaining three, "atheoretical," domains consists of the values or "fundamental motifs" which have been chosen from among a limited number of basic alternatives by a given historical group. The scholar forms a hypothesis regarding the fundamental motifs of the group in question; and if this hypothesis is verified by historical research, it then serves as a principle for organizing additional data concerning the group. Thus, the philosopher-historian of religion studies groups in an effort to determine their answers to the question, "What is the eternal?" It is chiefly in this domain that Nygren has applied his method, concluding, for example, that "agape" and "eros" are the characteristic Christian and Greek answers, respectively, to the fundamental religious question. Nygren maintains that this approach provides the means for treating the religious question systematically while simultaneously respecting the vast historical diversity of specific religious content. Just as the method of motif research is central to Nygren's work, so the discussion of that method and its applications constitutes, in effect, the central matter of this book. The project is carried off well. Nygren's final commentary is especially welcome, confirming or correcting positions presented by the contributors as his, and accepting or rejecting positions advanced by the contributors as their own.--J. M. V. (shrink)

In this paper we study the relations between the fragment L of classical logic having just conjunction and disjunction and the variety D of distributive lattices, within the context of Algebraic Logic. We prove that these relations cannot be fully expressed either with the tools of Blok and Pigozzi's theory of algebraizable logics or with the use of reduced matrices for L. However, these relations can be naturally formulated when we introduce a new notion of model of a sequent calculus. (...) When applied to a certain natural calculus for L, the resulting models are equivalent to a class of abstract logics (in the sense of Brown and Suszko) which we call distributive. Among other results, we prove that D is exactly the class of the algebraic reducts of the reduced models of L, that there is an embedding of the theories of L into the theories of the equational consequence (in the sense of Blok and Pigozzi) relative to D, and that for any algebra A of type (2,2) there is an isomorphism between the D-congruences of A and the models of L over A. In the second part of this paper (which will be published separately) we will also apply some results to give proofs with a logical flavour for several new or well-known lattice-theoretical properties. (shrink)

Tuberculosis (TB) is a potentially fatal infectious disease that, in Aotearoa New Zealand (NZ), inequitably affects Asian, Pacific, Middle Eastern, Latin American, and African (MELAA), and Māori people. Medical research involving genome sequencing of TB samples enables more nuanced understanding of disease strains and their transmission. This could inform highly specific health interventions. However, the collection and management of TB isolate samples for research are currently informed by monocultural biomedical models often lacking key ethical considerations. Drawing on a qualitative kaupapa (...) Māori–consistent study, this paper reports on preliminary discussions with groups of Māori, Pacific, and Afghan people in NZ, whose communities have been harmed by TB and TB stigma. Participants’ discussions highlight key concerns and meanings that ought to inform the development of guidelines and a more robust consultative process for the governance of how TB isolate samples are collected and used both retrospectively and in future research. We argue for ethical processes to be culturally nuanced and community-generated, flexible and meaningful, and situated in relation to the physical and symbolic effects of TB. We discuss the significance of Indigenous data sovereignty, rights, and kāwanatanga (governorship) in shaping a multicultural data sovereignty model. (shrink)

This paper explores some key discrepancies between two sets of normative requirements applicable to the research use of personal data and human biological materials: the data protection regime which follows the application of the European Union General Data Protection Regulation, and the Declaration of Helsinki, CIOMS guidelines and other research ethics regulations. One source of this controversy is that the GDPR requires consent to process personal data to be clear, concise, specific and granular, freely given and revocable and therefore has (...) challenged the concept of ‘broad consent’, which has been widely applied in the context of biobanking. Another source of controversy is the interplay between regulations of research ethics and protection of personal data related to the secondary use of personal data and biological materials. In this case, the GDPR ‘research condition’ provides an alternative to re-consent for the use of previously collected personal data and biological materials. Although the mentioned controversies have been raised in the legal literature, they have not been explicitly addressed from the research ethics perspective. Should consent be regarded as a priority legal basis for personal data processing in health data research? Can broad consent still be a suitable legal ground for biobanking? What should be the role of research ethics provisions that differ from the GDPR standards, and what should be the role and function of research ethics committees in the changing environment of health data research? These are the ongoing controversies to be explored in the paper. (shrink)

The rôle of mathematical models in growth studies is discussed and a distinction made between the structural and descriptive aspects of a mathematical formulation. A simple scheme is set up to represent in broad outline the simultaneous growth and interaction of larval and adult systems inMyrmica rubra and is matched against observed results.

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

Strategies that motivate agrifood producers to adopt more sustainable practices are a critical component for a sustainable future. This case study examines farmer attitudes to a recently released New Zealand agricultural policy aimed at improving freshwater quality by restricting agricultural activities. Our study interprets interviews of nine individuals managing a range of dairy and sheep farming operations to explore how these farmers manage societal expectations of being a ‘good farmer’ in the context of the new regulations. Four themes were developed (...) to capture perceptions of participants: the vested interest of farmers in positive community engagement and being seen as a ‘good’ farmer; the need to manage farms prudently for future generations; the unique geographical and environmental conditions on each farm and their concerns about the lack of acknowledgment of differences across land types in New Zealand; and the unintended consequences of the new regulations for rural communities. Overall, the themes suggest that the way the policy was enacted conflicts with perceptions of a ‘good farmer’ and good farming practice, resulting in identity conflicts for the farming community and reduced motivation to adopt alternative practices. (shrink)

BackgroundStreet-connected children and youth in low- and middle-income countries have multiple vulnerabilities in relation to participation in research. These require additional considerations that are responsive to their needs and the social, cultural, and economic context, while upholding core ethical principles of respect for persons, beneficence, and justice. The objective of this paper is to describe processes and outcomes of adapting ethical guidelines for SCCY’s specific vulnerabilities in LMIC.MethodsAs part of three interrelated research projects in western Kenya, we created procedures to (...) address SCCY’s vulnerabilities related to research participation within the local context. These consisted of identifying ethical considerations and solutions in relation to community engagement, equitable recruitment, informed consent, vulnerability to coercion, and responsibility to report.ResultsSubstantial community engagement provided input on SCCY’s participation in research, recruitment, and consent processes. We designed an assent process to support SCCY to make an informed decision regarding their participation in the research that respected their autonomy and their right to dissent, while safeguarding them in situations where their capacity to make an informed decision was diminished. To address issues related to coercion and access to care, we worked to reduce the unequal power dynamic through street outreach, and provided access to care regardless of research participation.ConclusionsAlthough a vulnerable population, the specific vulnerabilities of SCCY can to some extent be managed using innovative procedures. Engaging SCCY in ethical research is a matter of justice and will assist in reducing inequities and advancing their health and human dignity. (shrink)

Family involvement in healthcare decision-making for competent patients occurs to varying degrees in many communities around the world. There are different attitudes about who should make treatment decisions, how and why. Legal and professional ethics codes in most jurisdictions reflect and support the idea that competent patients should be enabled to make their own treatment decisions, even if others, including their healthcare professionals, disagree with them. This way of thinking contrasts with some cultural norms that put more emphasis on the (...) family as a decision-making entity, in some circumstances to the exclusion of a competent patient. Possible tensions may arise between various combinations of patient, family members and healthcare professionals, and healthcare professionals must tread a careful path in navigating family involvement in the decision-making process. These tensions may be about differences of opinion about which treatment option is best and/or on who should have a say or influence in the decision-making process. While some relevant cultural, legal and policy considerations vary from community to community, there are ethical issues that healthcare professionals need to grapple with in balancing the laws and professional codes on decision-making and the ethical principle of respecting patients and their autonomy. This paper will highlight and propose that a partial resolution to these issues may lie in relational understandings of autonomy, which in principle justify interventions by healthcare professionals and family that support patients in decision-making. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

The study of the “first wave” of reactions to the Critique of Pure Reason in Germany from the second half of the 1780s until the beginning of the nineteenth century reveals the paradoxical status of the Kantian transcendental subject. While the existence of the transcendental subject, whatever the term means, is not open to question since it arises from the very essence of critical philosophy, the fundamental status of the subject is sometimes questioned in this period. Although the meaning of (...) the concept of transcendental subject seems obvious today it lends itself to various interpretations in the late eighteenth century. To achieve my goal I have undertaken a textological analysis of the works of the earliest opponents and followers of the Kantian critique and a reconstruction of the conceptual field in the midst of which the transcendental subject has been planted. Among others I draw on the works of J. S. Beck, J. A. Eberhard, J. G. Hamann, F. H. Jacobi, S. Maimon, K. L. Reinhold, G. E. Schulze and A. Weishaupt. The authors of the period are grouped depending on the common themes and questions that prompted them to turn to the concept of the transcendental subject, even though the results of their reflections did not always coincide. These authors think of the transcendental subject in its relationship to the transcendental object, or as “something = х”, and in terms of the relationship of representation to the object. It is characterised sometimes as something absolutely hollow, and sometimes as the fullness of true reality. The status ascribed to the transcendental subject is sometimes that of a thing-in-itself and sometimes that of a “mere” idea. Finally, Kant’s transcendental subject was sometimes seen as something to be overcome and sometimes as an infinite challenge to understanding. (shrink)

OBJECTIVES: To investigate the need for hospital clinical ethics committees by studying the frequency with which ethical dilemmas arose, the perceived adequacy of the process of their resolution, and the teaching and training of staff in medical ethics. DESIGN: Interviews with individuals and three multidisciplinary teams; questionnaire to randomly selected individuals. SETTING: Two major London children's hospitals. RESULTS: Ethical dilemmas arose frequently but were resolved in a relatively unstructured fashion. Ethical concerns included: the validity of consent for investigations and treatment; (...) lack of children's involvement in consent; initiation of heroic or futile treatments; resource allocation. Staff expressed the need for a forum which would provide consultation on ethical issues, develop guidelines for good ethical practice, undertake teaching and training, and provide ethical reflection outside the acute clinical setting. CONCLUSION: Multidisciplinary, accountable and audited clinical ethics committees with predominantly advisory, practice development and educational roles could provide a valuable contribution to UK clinical practice and perhaps in other countries that have not developed hospital clinical ethics committees. (shrink)

The choroid plexuses (CPs) are involved in the most-basic aspects of neural function including maintaining the extracellular milieu of the brain by actively modulating chemical exchange between the CSF and brain parenchyma, surveying the chemical and immunological status of the brain, detoxifying the brain, secreting a nutritive “cocktail” of polypeptides and participating in repair processes following trauma. This diversity of functions may mean that even modest changes in the CP can have far-reaching effects. Indeed, changes in the anatomy and physiology (...) of the CP have been linked to aging and several CNS diseases. It is also possible that replacing diseased or transplanting healthy CP might be useful for treating acute and chronic brain diseases. This review focuses on the wide-ranging and under-appreciated functions of the CP, alterations of these functions in aging and neurodegeneration, and recent demonstrations of the therapeutic potential of transplanted CP for neural trauma. BioEssays 27:262–274, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Aristotle and the sea battle, by G. E. M. Anscombe.--Aristotle's different possibilities, by K. J. J. Hintikka.--On Aristotle's square of opposition, by M. Thompson.--Categories in Aristotle and in Kant, by J. C. Wilson.--Aristotle's Categories, chapters I-V: translation and notes, by J. L. Ackrill--Aristotle's theory of categories, by J. M. E. Moravcsik.--Essence and accident, by I. M. Copi.--Tithenai ta phainomena, by G. E. L. Owen.--Matter and predication in Aristotle, by J. Owens.--Problems in Metaphysics Z, chapter 13, by M. J. Woods.--The meaning (...) of agathon in the Ethics of Aristotle, by H. A. Prichard.--Agathon and eudaimonia in the Ethics of Aristotle, by J. L. Austin.--The final good in Aristotle's Ethics, by W. F. R. Hardie.--Aristotle on pleasure, by J. O. Urmson.--Bibliography (p. 335-41). (shrink)

Open peer commentary on the article “Exploration of the Functional Properties of Interaction: Computer Models and Pointers for Theory” by Etienne B. Roesch, Matthew Spencer, Slawomir J. Nasuto, Thomas Tanay & J. Mark Bishop. Upshot: Although the authors investigate a form of distributed swarm intelligence and solve some problems with it – including sorting and summing – the major goal, which is constructing cognition, cannot be achieved by this approach alone. I propose that anticipatory mechanisms have the potential to construct (...) cognition and may very well be combined with swarm intelligence principles. (shrink)